Patent · US Expired

Synthesis of cyclic peptides

US5726287A · kind A · utility

42Cited by

15References

9Claims

0Family size

Assignee

Ferring AB · SE

Inventors

Lars Henrik Harald Andersson · Gately Drive, SE
Jan-Ake Skoldback · Malmö, SE

Key dates

Filing date	Jun 20, 1996
Grant date	Mar 10, 1998
Priority date	—
Expiry date	Jun 20, 2016

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A process for preparing and purifying cyclic peptides having disulfide moieties in a single processing operation which simplifies synthesis and reduces production costs, yet produces high, quality yield. Higher yields are obtained by isolating the desired cyclic compound through direct ion exchange chromatography as an integral part of the single process. The improved process is particularly useful for the preparation of vasopressin and oxytocin and their respective derivatives and analogs.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.