Localization and characterization of the Wilms' tumor gene
US5726288A · kind A · utility
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Key dates
| Filing date | Aug 2, 1993 |
| Grant date | Mar 10, 1998 |
| Priority date | — |
| Expiry date | Aug 2, 2013 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/57438
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The Wilms' tumor gene associated with 11p3 locus on the human chromosome, as well as a method of analyzing cells for the gene is described and characterized. The gene encodes a transcription unit approximately 50 kb in size and a mRNA of approximately 3 kb, which is expressed in predominantly in kidney and gonadal tissue. The gene is alternative spliced producing four very similar mRNA transcripts. The polypeptides encoded by the Wilms' tumor DNA includes four "zinc fingers" and a region rich in proline and glutamine, suggesting that the polypeptide has a role in transcription regulation.
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