Porphocyanine and CNC-expanded porphyrins
US5726304A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 26, 1994 |
| Grant date | Mar 10, 1998 |
| Priority date | — |
| Expiry date | Apr 26, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/22
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of the formula ##STR1## and the metalated forms and salts thereof; wherein n is an integer of 1-4; and PA1 wherein each P.sub.i is independently a pyrrole residue of the formula ##STR2## wherein each R.sub.ia and R.sub.ib is independently a noninterfering substituent, and PA1 wherein each Z.sub.i is independently a covalent bond; or is PA1 a meso bridging group of the formula ##STR3## or is an N-meso bridging group of the formula EQU .dbd.N--.revreaction.--N.dbd.; or is PA1 a CC linkage of the formula ##STR4## or is a CNCCNC linkage of the formula ##STR5## wherein each R.sub.ic, R.sub.id, R.sub.ie, R.sub.if and R.sub.ig is independently a noninterfering substituent; or is PA1 a CNC linkage of the formula EQU --CH.dbd.N--CH.dbd..revreaction..dbd.CH--N.dbd.CH-- PA1 wherein at least one Z.sub.i is said CNC linkage, are disclosed. These compounds are useful in photodynamic therapy and diagnosis. The metalated forms when the metal is paramagnetic are useful as MRI contrast agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.