Process for the stereoselective preparation of a .beta.-phenylisoserine derivative and its use for the preparation of taxane derivatives
US5726346A · kind A · utility
1Cited by
1References
17Claims
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Key dates
| Filing date | Apr 5, 1995 |
| Grant date | Mar 10, 1998 |
| Priority date | — |
| Expiry date | Apr 5, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to a method of stereoselective preparation of a derivative of .beta.-phenylisoserine of formula (I) by the action of an N-carbonyl-benzylimine of formula (II) on an optically active amide of a protected hydroxyacetic acid of formula (III), followed by hydrolysis of the product obtained. In formula (I), (II) or (III), R is an optionally substituted phenyl radical or R.sub.1 --O, Ar is an optionally substituted aryl radical and G.sub.1 is a hydroxy function protection grouping. The product of formula (I) is particularly useful in preparing taxol and Taxotere which have remarkable antitumor properties. ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.