Effervescent ranitidine formulations
US5728401A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 16, 1997 |
| Grant date | Mar 17, 1998 |
| Priority date | — |
| Expiry date | Apr 16, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/0007
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An effervescent pharmaceutical composition for oral use in the treatment of a condition mediated through histamine H.sub.2 receptors contains a therapeutically effective amount of ranitidine or a physiologically acceptable salt thereof, about 25-70% by weight of disodium citrate, and about 20-50% by weight of sodium bicarbonate. Optionally, the effervescent composition may also Include about 0.5-25% by weight of an edible organic acid such as fumaric acid. Preferably, the effervescent composition is in the form of a tablet. Additional excipients for the effervescent composition include about 2-10% by weight of glycine, a flavoring agent, a sweetening agent, a binding agent, and/or a lubricant.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.