Cloning and recombinant production of CRF receptor (S)
US5728545A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 23, 1993 |
| Grant date | Mar 17, 1998 |
| Priority date | — |
| Expiry date | Aug 23, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/72
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
In accordance with the present invention, there are provided novel G-protein-coupled receptor proteins (CRF-R) characterized by having sufficient binding affinity for corticotropin releasing factor (CRF) such that concentrations of .ltoreq.10 nM of CRF occupy .gtoreq.50% of the binding sites of said receptor protein. Nucleic acid sequences encoding such receptors, assays employing same, as well as antibodies derived therefrom, are also disclosed. The invention CRF-R can be employed in a variety of ways, such as, for example, in bioassays, for production of antibodies thereto, in therapeutic compositions containing such proteins and/or antibodies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.