High purity albumin and method of producing
US5728553A · kind A · utility
96Cited by
9References
12Claims
0Family size
Assignee
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Key dates
| Filing date | May 25, 1995 |
| Grant date | Mar 17, 1998 |
| Priority date | — |
| Expiry date | May 25, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process for the preparation of albumin which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, fragments of albumin, polymers or aggregates of albumin, and viruses, and which is relatively non-glycated, relatively high in free thiol and with an intact C-terminus. The process comprises passing albumin (preferably expressed and secreted by transformed yeast) through two chromatography purifications, ultrafiltering the product, passing through two further chromatography steps and again ultrafiltering the product.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.