Method of inducing vasorelaxation to treat pulmonary hypertension

US5728705A · kind A · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Charles A. Lawson · Verona, US
• David Pinsky · Yonkers, US
• Arthur Smerling · New Rochelle, US
• David M. Stern · Great Neck, US

Key dates

• Filing date: Oct 4, 1993
• Grant date: Mar 17, 1998
• Expiry date: Oct 4, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/52
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides a method of selectively decreasing pulmonary vascular resistance in a subject by administering endobronchially a drug chosen from among cAMP analogs, cGMP analogs, phosphodiesterase inhibitors, nitric oxide precursors, nitric oxide donors, and nitric oxide analogs.