Process for making an epoxide

US5728840A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• David Askin · Hackettstown, US
• Kan K. Eng · Jersey City, US
• Peter E. Maligres · Fanwood, US
• Paul J. Reider · Westfield, US
• Kai Rossen · Hanau, DE
• Ralph P. Volante · Rahway, US
• Veena Upadhyay · Westfield, US
• Steven A. Weissman · Little Falls, US

Key dates

• Filing date: Aug 8, 1995
• Grant date: Mar 17, 1998
• Expiry date: Aug 8, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D263/52
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for synthesizing the epoxide of the formula ##STR1## consists of, at a minimum, formation of a halohydrin from the allyl acetonide reactat, followed by base-induced cyclization, the epoxide product I being useful as an intermediate for the synthesis of inhibitors of renin or HIV protease or other proteases.