Taxoids their preparation and pharmaceutical compositions containing them
US5728849A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 20, 1996 |
| Grant date | Mar 17, 1998 |
| Priority date | — |
| Expiry date | Dec 20, 2016 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
New taxoids of general formula (I): ##STR1## wherein Z represents a hydrogen atom or a radical of general formula: ##STR2## in which R.sub.1 represents an optionally substituted benzoyl radical, a thenoyl or furoyl radical or a radical R.sub.2 --O--CO-- in which R.sub.2 represents an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl or phenyl radical, optionally substituted, or a heterocyclic radical, PA1 R.sub.3 represents an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, phenyl, naphthyl or aromatic heterocyclic radical, PA2 either R.sub.4 represents a hydrogen atom, PA2 R.sub.6 and R.sub.7 together form a ketone function, and PA2 R and R.sub.5 together form a bond, PA2 or R.sub.4 represents a hydrogen atom or a PA1 hydroxyl radical or an alkoxy, alkenyloxy or alkynyloxy radical, optionally substituted, an alkanoyloxy, aryloxy, alkenoyloxy, alkynoyloxy, cycloalkanoyloxy, alkoxyacetyl, alkylthioacetyl, alkyloxycarbonyloxy, cycloalkyloxy, cycloalkenyloxy, carbamoyloxy, alkylcarbamoyloxy or dialkylcarbamoyloxy radical, PA2 R.sub.5 represents a hydrogen atom, PA2 or R.sub.4 and R.sub.5 together form a ketone function PA2 R.sub.6 represents a hydrogen atom, and PA2 R…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.