Resolution of the racemates of primary and secondary amines by enzyme-catalyzed acylation

US5728876A · kind A · utility

Assignee

• BASF SE

Inventors

• Friedhelm Balkenhohl · Schifferstadt, DE
• Bernhard Hauer · Neheim, DE
• Wolfgang Ladner
• Uwe Pressler · Altrip, DE
• Christoph Nubling · Haßloch, DE

Key dates

• Filing date: Mar 11, 1996
• Grant date: Mar 17, 1998
• Expiry date: Mar 11, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P41/007
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A process for producing optically active primary and secondary amines from the corresponding racemates is characterised in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bears a fluorine, nitrogen, oxygen or sulphur atom at the proximity of the carbonyl carbon atom; (b) the mixture of optically active amine and optically active acylated amine is separated so that an enantiomer of amine is produced; (c) if desired the other enantiomer of the amine is extracted from the acylated amine by amide cleavage.