Immunogens for the production of cocaine-hydrolyzing catalytic antibodies
US5730985A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 13, 1994 |
| Grant date | Mar 24, 1998 |
| Priority date | — |
| Expiry date | Jun 13, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/627
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods are described for the rapid synthesis in satisfactory yield of methyl ecgonine phenylphosphonates as analogues of transition states for the hydrolysis of the benzoyl ester of an ecgonine derivative, namely cocaine, and their linking to carrier proteins, for the purpose of using them as immunogens. The resulting immunogens elicit the formation in experimental animals of antibodies able to promote the hydrolysis of cocaine. Both these catalytic anti-cocaine antibodies and the immunogens themselves are potentially useful for the treatment of individuals seeking to avoid the pharmacological effects of cocaine and in diagnostic applications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.