Compositions for inhibition of intracellular transcription factors and methods therefor
US5731155A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 2, 1996 |
| Grant date | Mar 24, 1998 |
| Priority date | — |
| Expiry date | Jul 2, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel compositions and methods for inhibiting cytokine-induced intracellular activation of STAT family transcription factors by binding to the transcription factors and inhibiting the transcriptional activity of the factors are disclosed. The method comprises introducing into a cell an effective amount of a peptide or derivative thereof, in which the peptide contains a sequence that is derived from a receptor for the cytokine, but with a tyrosine residue being phosphorylated. The compositions comprise isolated peptides or derivatives thereof in which the peptide contains an amino acid sequence derived from a receptor for a cytokine but with a tyrosine residue phosphorylated. A method for identifying derivatives of the isolated peptides comprising detecting the inhibition of the binding of said peptide to a STAT family transcription factor by said derivative is also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.