Method of producing (R)-2-amino-1-phenylethanol and optically active phenylserine and their halogen substituted products using microbes
US5731175A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 29, 1996 |
| Grant date | Mar 24, 1998 |
| Priority date | — |
| Expiry date | Aug 29, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P41/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Tyrosine decarboxylase, or microorganisms of the genuses Enterococcus, Lactobacillus, Providencia, Fusarium, and Gibberella were reacted with a mixture of the enantiomers of threo-3-phenylserine or its halogen substitution products to produce (R)-2-amino-1-phenylethanol or its halogen substitution products. At the same time, one of the enantiomers of threo-3-phenylserine or its halogen substitution products were selectively left, and optically active threo-3-phenylserine or its halogen substitution products were produced. In addition, a novel material of 3-(3-chlorophenyl)serine, which is a substrate of the reaction in the present invention, was produced. (R)-2-amino-1-phenylethanol or its halogen substitution products, and optically active threo-3-phenylserine or its halogen substitution products can economically be produced on an industrial scale.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.