Tachiquinine antagonist tricyclic compounds, preparation of same and pharmaceutical compositions containing such compounds

US5731285A · kind A · utility

Assignees

• A. Menatini Industrie Farmaceutiche · IT
• LABORATORI GUIDOTTI S.P.A. · IT
• Malesci Istituto Farmacobiologico S.p.A. · IT

Inventors

• Vincenzo Pavone · Napoli, IT
• Angelina Lombardi · Guardia Sanframondi, IT
• Carlo Pedone · Napoli, IT
• Carlo Alberto Maggi · Firenze, IT
• Laura Quartara · Campi Bisenzio, IT

Key dates

• Filing date: Oct 17, 1996
• Grant date: Mar 24, 1998
• Expiry date: Oct 17, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Tachyikinin antagonist compounds of the general formula: ##STR1## are described where: X1, X2, X3, X4, X5, and X6 are identical or different and are --NR'--CO-- or --CO--NR"--, where R' is H or C.sub.1-3 alkyl; PA1 Y is --CONR--, --NRCO--, OCO, --COO--, --CH.sub.2 --NR--, --NR--CH.sub.2 --, --SS--, --CH.sub.2 --CH.sub.2 --, cis or trans --CH.dbd.CH-- where R is H or C.sub.1-3 alkyl; PA1 R1, R2, R3, and R4 are each a hydrophobic group; PA1 n and m are identical or different and are each a whole number from 1 to 4. The preparation and pharmaceutical compositions of the compounds are also disclosed.