Glycoprotein IIb/IIIa antagonists

US5731324A · kind A · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Matthew Joseph Fisher · Mooresville, US
• Anne Marie Happ · Indianapolis, US
• Joseph A. Jakubowski · Indianapolis, US
• Michael Dean Kinnick · Indianapolis, US
• Allen D. Kline · Bargersville, US
• Michael John Martinelli · Indianapolis, US
• John Michael Morin, Jr. · Brownsburg, US
• Michael Paal · Hamburg, DE
• Gerd Ruhter · Hamburg, DE
• Kenneth J. Ruterbories · Indianapolis, US
• Daniel Jon Sall · Greenwood, US
• Theo Schotten · Winsen (Luhe), DE
• Marshall A. Skelton · Indianapolis, US
• Wolfgang Stenzel · Reinbek, DE
• Robert Theodore Vasileff · Indianapolis, US

Key dates

• Filing date: Jan 19, 1995
• Grant date: Mar 24, 1998
• Expiry date: Jan 19, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, benzopyran, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.