Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use and process for their production

US5733522A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Heribert Schmitt-Willich · Berlin, DE
• Johannes Platzek · Berlin, DE
• Heinz Gries · Berlin, DE
• Bernd Raduchel · Berlin, DE
• Orlin Petrov · Berlin, DE
• Andreas Muhler · Oderberg, DE
• Thomas Frenzel · Berlin, DE
• Hubert Vogler · Berlin, DE
• Hans Bauer · Dana Point, US
• Klaus Nickisch · Berlin, DE
• Jean-Claude Hilscher · Berlin, DE

Key dates

• Filing date: Sep 29, 1995
• Grant date: Mar 31, 1998
• Expiry date: Sep 29, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/24
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to complex compound as well as their salts consisting of at least one metal ion and one complexing agent of general formula I ##STR1## in which Z.sup.1, Z.sup.2 and s have different meanings, as well as their use for the production of agents for radiation therapy and for NMR diagnosis and diagnostic radiology, especially for contrasting the hepatobiliary system. Further, the invention relates to a process for the production of these compounds and agents.