Peptides including amino acid sequences selected from lipoprotein (a) and apolipoprotein (a), antibodies recognizing these amino acid sequences, and methods of determination using these antibodies
US5733549A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 14, 1994 |
| Grant date | Mar 31, 1998 |
| Priority date | — |
| Expiry date | Apr 14, 2014 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/92
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Amino acid sequences having specificity as lipoprotein (a) and low homology with LDL and plasminogen are selected from the amino acid sequence of lipoprotein (a), and antibodies to lipoprotein (a) which recognize these amino acid sequences specifically are obtained. At least one of these antibodies is used in immunological techniques for the determination of lipoprotein (a). Moreover, an amino acid sequence having specificity as apolipoprotein (a) and not having antigenicity as lipoprotein (a) or plasminogen is selected from the amino acid sequence of apolipoprotein (a), and antibodies to apolipoprotein (a) which recognize this amino acid sequence specifically are obtained. At least one of these antibodies is used in immunological techniques for the determination of apolipoprotein (a). As compared with prior art methods, antibodies to lipoprotein (a) and apolipoprotein (a) can be obtained according to a simplified procedure, and their use makes it possible to determine lipoprotein (a) and apolipoprotein (a) accurately.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.