Avian herpesvirus-based live recombinant avian vaccine, in particular against Gumboro disease
US5733554A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 5, 1995 |
| Grant date | Mar 31, 1998 |
| Priority date | — |
| Expiry date | Jan 5, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/20022
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to vaccines for avian use which are based on live recombinant avian herpesviruses, in particular the Marek's disease viruses including HVT virus (herpesvirus of turkey), in which has been inserted, by genetic recombination, at least one nucleotide sequence which encodes and expresses an antigenic polypeptide of an avian pathogen under conditions which ensure immunization leading to efficient protection of the vaccinated animal against the pathogen. In one embodiment, the antigenic polypeptide is inserted in the UL43 gene under the control of the CMV immediate early promoter. The vaccines of the present invention are advantageous over previously used vaccines in that they can be used to ensure total protection of animals against Gumboro disease and to immunize chicks as young as one-day old without secondary effects, and only require low doses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.