Method of treating endo-osteal materials with a bisphosphonate solution

US5733564A · kind A · utility

Assignee

• Leiras Oy · FI

Inventor

• Risto Lehtinen · Helsinki, FI

Key dates

• Filing date: Sep 19, 1995
• Grant date: Mar 31, 1998
• Expiry date: Sep 19, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/02
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

An endo-osteal material which includes an endo-osteal material treated with a solution of a bisphosphonate of formula (1) wherein X is H, OH, Cl, F or a methyl group and Y is Cl, OH, --(CH.sub.2).sub.2 --N(CH.sub.3)--(CH.sub.2).sub.4 --CH.sub.3, --(CH.sub.2).sub.n --CH.sub.3 or --(CH.sub.2).sub.n --NH.sub.2, where n is zero or an integer being 1 to 8, --NHZ, where Z is pyridinyl or cycloheptyl, SZ', where Z' is pyridinyl or chlorosubstituted phenyl or Y is a pyridinylsubstituted lower alkyl chain; or a non-toxic, pharmaceutically acceptable salt or ester thereof dissolved in an appropriate solvent. ##STR1##