Peptides and proteins, process for their preparation and their use as cholesterol acceptors

US5733879A · kind A · utility

Assignee

• N.V. Innogenetics S.A. · BE

Inventors

• Maryvonne Rosseneu · Brugge, BE
• Robert Brasseur · Haillot, BE
• Robert Deleys · Grimbergen, BE
• Christine Labeur · Brugge, BE

Key dates

• Filing date: Dec 23, 1994
• Grant date: Mar 31, 1998
• Expiry date: Dec 23, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The subject invention relates to amino acid sequences derived from peptide (Glu.sup.1,8, Leu.sup.11,17) 18A, comprising: PA1 Glu-Trp-Leu-A-Ala-B-Tyr-C-Lys-Val-D-Glu-Lys-Leu-Lys-Glu-Leu-Phe, wherein A is Lys, Glu or Asp; B is Phe, Glu or Asp; C is Glu, Lys or Arg; and D is Leu, Glu or Asp. The amino acid sequences form complexes with phospholipids, and are useful for the treatment of cardiovascular disease.