Method of promoting adhesion between tissue surfaces
US5736132A · kind A · utility
99Cited by
8References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 29, 1996 |
| Grant date | Apr 7, 1998 |
| Priority date | — |
| Expiry date | Jan 29, 2016 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/85
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A formulated biological adhesive composition utilizes tissue transglutaminase in a pharmaceutically acceptable aqueous carrier. The tissue transglutaminase is used in an effective catalytic amount to promote adhesion between tissue surfaces upon treatment thereof by catalyzing the reaction between glutaminyl residues and amine donors of the tissue and/or the enzyme. The carrier contains a divalent metal ion such as calcium to promote said reaction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.