Monoclonal antibodies with specific binding against membrane proteins on human cells, and pharmaceutical compositions containing them

US5736138A · kind A · utility

Assignees

• Klaus Pfizenmaier · DE
• Peter Scheurich · DE
• Bettina Thoma · DE

Inventors

• Klaus Pfizenmaier · Tiefenbronn, DE
• Peter Scheurich · Stuttgart, DE
• Bettina Thoma · Bocholt, DE

Key dates

• Filing date: Feb 12, 1991
• Grant date: Apr 7, 1998
• Expiry date: Feb 12, 2011

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/866
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A monoclonal antibody, or fragments thereof, against human TNF receptor protein which antibody neutralizes the known actions of TNF.alpha. and/or TNF.beta. is disclosed. The antibody may be chimeric or humanized. Furthermore, the present invention provides a process for obtaining the above monoclonal antibody, as well as a pharmaceutical composition containing the above monoclonal antibody and/or the above protein with antibody properties.