Method to prevent fertilization in mammals by administering a single dose of zona pellucida derived antigens, liposome and Freund's adjuvant
US5736141A · kind A · utility
12Cited by
5References
6Claims
0Family size
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Key dates
| Filing date | Oct 30, 1996 |
| Grant date | Apr 7, 1998 |
| Priority date | — |
| Expiry date | Oct 30, 2016 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/853
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A vaccine for the immunocontraception of mammals is described. The vaccine consists of zona pellucida antigens and an adjuvant encapsulated in a liposome delivery system. The liposome delivery system allows for the slow release of antigen resulting in a prolonged immune response. In particular, after a single injection of the vaccine, levels of anti-zona pellucida antibodies were detected for up to 22 months in seals. Thus, the vaccine according to the present invention is effective after a single dose and is therefore very useful in immunocontraceptive protocols.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.