Method of diagnosing Neoplastic disease by detecting increased expression of human MDM2 protein

US5736338A · kind A · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Marilee Burrell · Cambridge, US
• David E. Hill · Gardner, US
• Kenneth W. Kinzler · Baltimore, US
• Bert Vogelstein · Baltimore, US

Key dates

• Filing date: Feb 17, 1995
• Grant date: Apr 7, 1998
• Expiry date: Feb 17, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S436/813
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

In certain human tumor cells, the gene encoding MDM2 protein is amplified and expression of MDM2 protein is elevated. Since human MDM2 protein binds to human p53, excess MDM2 protein apparently releases a cell from p53-regulated growth. Detection of elevated amounts of human MDM2 protein thus can be used to diagnose neoplastic disease in a human.