Cytokine-, stress-, and oncoprotein-activated human protein kinase kinases
US5736381A · kind A · utility
11Cited by
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20Claims
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Key dates
| Filing date | Sep 19, 1995 |
| Grant date | Apr 7, 1998 |
| Priority date | — |
| Expiry date | Sep 19, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/143333
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are human mitogen-activated (MAP) kinase kinase isoforms (MKKs). MKKs mediate unique signal transduction pathways that activate human MAP kinases p38 and JNK, which result in activation of other factors, including activating transcription factor-2 (ATF2) and c-Jun. The pathways are activated by a number of factors, including cytokines and environmental stress. Methods are provided for identifying reagents that modulate MKK function or activity and for the use of such reagents in the treatment of MKK-mediated disorders.
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