Patent · US Expired

Bacteriophage-mediated gene transfer systems capable of transfecting eukaryotic cells

US5736388A · kind A · utility

29Cited by
0References
4Claims
0Family size

Inventors

Key dates

Filing dateDec 30, 1994
Grant dateApr 7, 1998
Priority date—
Expiry dateDec 30, 2014

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2800/202
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Lamboid bacteriophage capable of specifically interacting with and delivering nucleic acid molecules to eukaryotic cells are disclosed. Such bacteriophage-derived gene transfer systems target one or more specific receptors on eukaryotic cells, for instance by incorporating mutant tail fiber proteins or by incorporating known ligands for specific eukaryotic receptors into lambda phage. Also disclosed are methods for identifying and producing modified bacteriophage tail fiber polypeptides capable of specifically interacting with eukaryotic transmembrane proteins. Methods of treating diseases using such gene transfer systems are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.