Lineage-directed induction of human mesenchymal stem cell differentiation
US5736396A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 24, 1995 |
| Grant date | Apr 7, 1998 |
| Priority date | — |
| Expiry date | Jan 24, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/39
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for in vitro or ex vivo lineage directed induction of isolated, culture expanded human mesenchymal stem cells comprising contacting the mesenchymal stem cells with a bioactive factor effective to induce differentiation thereof into a lineage of choice as well as such compositions including isolated culture expanded human mesenchymal stem cells and bioactive factors effective to induce directed lineage induction are disclosed. Further disclosed is this method which also includes introducing such culturally expanded lineage-induced mesenchymal stem cells into a host from which they have originated for purposes of mesenchymal tissue regeneration or repair.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.