1-pyrimidinylacetamide compounds which are inhibitors of human leukocyte elastase
US5736535A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 19, 1995 |
| Grant date | Apr 7, 1998 |
| Priority date | — |
| Expiry date | Jan 19, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to certain novel substituted derivatives which are 1-pyrimidinylacetamide derivatives of formula I, ##STR1## which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these substituted derivatives, processes for preparing the substituted derivatives, pharmaceutical compositions containing such substituted derivatives and methods for their use.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.