Patent · US Expired

Drug delivery agents incorporating mitomycin

US5738864A · kind A · utility

14Cited by
0References
26Claims
0Family size

Assignee

Inventors

Key dates

Filing dateFeb 20, 1996
Grant dateApr 14, 1998
Priority date—
Expiry dateFeb 20, 2016

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61K47/65
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

A conjugate of a carrier polymer and aziridine ring containing mitomycin (MMC) drug molecules is prepared by coupling the MMC molecules via their aziridine imino groups to spacer groups that terminate in protected amino groups, deprotecting said amino groups, recovering and purifying the spacer-MMC derivatives, and then coupling these derivatives via said deprotected amino groups to the carrier polymer. Alternatively, the MMC may first be treated with an activating agent, e.g. carbodiimidazole, to form an activated MMC derivative which is then coupled directly to spacer groups linked to the carrier polymer.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.