Peptidyl 4-amino-2,2-difluoro-3-oxo-1,6-hexanedioic acid derivatives as antiinflammatory agents
US5739279A · kind A · utility
2Cited by
0References
12Claims
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Assignee
Inventor
Key dates
| Filing date | Jan 26, 1995 |
| Grant date | Apr 14, 1998 |
| Priority date | — |
| Expiry date | Jan 26, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to compounds of formula (A) which are derivatives of 4-amino-2,2-difluoro-3-oxo-1,6-hexanedioic acid and their pharmaceutically acceptable base salts. These derivatives and salts thereof are useful for inhibiting interleukin 1.beta. converting enzyme and for treating inflammatory conditions in mammals. The invention also claims three (3) intermediates which are useful for the preparation of said derivatives and salts.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.