Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents
US5739294A · kind A · utility
19Cited by
23References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 3, 1994 |
| Grant date | Apr 14, 1998 |
| Priority date | — |
| Expiry date | Aug 3, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/6561
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Bicyclopolyazamacrocyclophosphonic acid compounds are disclosed which may form inert complexes with Gd, Mn or Fe ions. The overall charge of the complex can be varied to alter the in vivo biolocalization. Such complexes can be covalently attached to an antibody, antibody fragment or other biologically active molecule to form conjugates. The complexes and conjugates are useful as contrast agents for diagnostic purposes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.