Synthesis of acetogenins
US5739358A · kind A · utility
1Cited by
1References
7Claims
0Family size
Assignee
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Key dates
| Filing date | May 13, 1997 |
| Grant date | Apr 14, 1998 |
| Priority date | — |
| Expiry date | May 13, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/58
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for the synthesis of bis-tetrahydrofuranyl annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enzyme.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.