Intermediates for the synthesis of bisphosphine compounds

US5739360A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Wolfram Sirges · Düsseldorf, DE
• Christian Laue · Monheim, DE
• Dieter Arlt · Cologne, DE
• Rolf Grosser · Schwandorf, DE

Key dates

• Filing date: Sep 16, 1996
• Grant date: Apr 14, 1998
• Expiry date: Sep 16, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65517
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to novel bisphosphonates and to processes for their preparation and for their resolution into the enantiomers. The bisphosphonates according to the invention are valuable intermediates for the preparation of bisphosphine compounds, especially chiral bisphosphine ligands. These in turn are constituents of transition metal complexes which are used as catalysts inter alia in asymmetric hydrogenation. The novel bisphosphonates have the general formula (I) ##STR1## in which R.sup.1 is linear or branched alkyl having up to 6 carbon atoms, aryl or aralkyl, each of which can optionally be substituted, or two radicals R.sup.1 together are a bridging hydrocarbon radical having up to 6 carbon atoms, PA1 and can exist in the form of their racemates or as enantiomers.