Sphingosomes for enhanced drug delivery
US5741516A · kind A · utility
155Cited by
5References
35Claims
0Family size
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Key dates
| Filing date | Dec 14, 1995 |
| Grant date | Apr 21, 1998 |
| Priority date | — |
| Expiry date | Dec 14, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1278
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Liposomal formulations having extended circulation time in vivo and increased drug retention are comprised of sphingomyelin and cholesterol and have an acidic intraliposomal pH. The formulations have enhanced stability and thus are used in methods which provide improved drug delivery and more effective treatment. The delivery of ciprofloxacin, and alkaloid drugs, particularly swainsonine, vincristine and vinblastine, is significantly improved.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.