Histidine compositions and methods for treating or preventing infectious and non-infectious diarrheas
US5741807A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Sep 27, 1996 |
| Grant date | Apr 21, 1998 |
| Priority date | — |
| Expiry date | Sep 27, 2016 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of preventing or reducing fluid and electrolyte losses in mammalian subjects under the effect of a stimulus that directly or indirectly causes such losses, by administering a therapeutically effective amount of D-histidine, L-histidine, a racemic mixture thereof, a non-racemic mixture thereof, and pharmaceutically acceptable salts in conjunction with a carrier. In one embodiment the method is useful in reducing or preventing intestinal tract fluid secretions, and fluid and electrolyte losses associated with diarrhea arising from a number of causative agents, such as infectious diarrheas and non-infectious diarrheas. Various therapeutic regimes of histidine administration and formulation are embodied. Therapeutic compositions of histidine in combination with other medicaments, e.g., those that produce a diarrheal side-effect, are disclosed as another embodiment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.