Diagnosis and treatment of cancer having clonal macrophage involvement
US5744122A · kind A · utility
12Cited by
11References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 15, 1996 |
| Grant date | Apr 28, 1998 |
| Priority date | — |
| Expiry date | Feb 15, 2016 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/81
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The presence of clonal macrophages in pre-cancerous and cancerous tissue represents an early stage of the disease in which clonal expansion of macrophages occurs due to HIV integration or other genetic mutation. Clonally expanded macrophages induce proliferation of surrounding tissue leading to cancerous tumor growth. The invention provides methods and kits for diagnosis of HIV- and non-HIV-associated clonal expansion of macrophages in pre-cancerous and cancerous tissue. The invention also provides methods for the treatment of cancers induced by clonal macrophage expansion and proliferation of surrounding tissue.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.