Calcineurin inhibitory compounds and anchoring protein to induce IL-2 gene expression
US5744354A · kind A · utility
2Cited by
7References
6Claims
0Family size
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Key dates
| Filing date | Mar 15, 1995 |
| Grant date | Apr 28, 1998 |
| Priority date | — |
| Expiry date | Mar 15, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/16
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides compositions and methods useful for isolating calcineurin as well as inhibiting calcineurin activity. The compositions are peptides that contain regions that are homologous to calcineurin-binding regions of AKAP 79. Also provided are methods for determining if a cell contains a calcineurin-binding and PKA-binding anchoring protein that are useful for identifying additional proteins that bind both calcineurin and PKA. Another aspect of the present invention is methods for enhancing expression of interleukin 2 by T cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.