HPTH-fragment-(1-37), the preparation thereof, medicaments containing same and the use thereof

US5744444A · kind A · utility

Assignee

• Haemopep Pharma GmbH · DE

Inventors

• Wolf-Georg Forssmann · Hannover, DE
• Franz Herbst · Leimen, DE
• Peter Schulz-Knappe · Hemmingen, DE
• Knut Adermann · Hannover, DE
• Michael Gagelmann · Schriesheim, DE

Key dates

• Filing date: May 12, 1995
• Grant date: Apr 28, 1998
• Expiry date: May 12, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a peptide from human blood, designated as hPTH-(1-37), the structure of which was elucidated for the purpose of the diagnostic, medical and commercial utilization thereof. The isolation of a fragment hPTH-(38-84) proves the existence of the hPTH-(1-37). A removal of amino-terminal amino acids from the hPTH fragment-(1-37) reduces its biological activity. The hPTH-(1-37) circulating in the blood is identical with the synthetic reference substance hPTH-(1-37), however not with fragments such as hPTH-(1-33), hPTH-(1-34) or hPTH-(1-38). The molecule form hPTH-(1-37) has been proven by mass spectrometry (plasma desorption method). A different biological activity and differences in the three-dimensional peptide structure of the hPTH fragment-(1-37) in comparison to other hPTH fragments furnish evidence of that this fragment is the preferential natural peptide of the parathormone family which should be used for the treatment of diseases of the parathyroid, circulatory system, respiratory system, male genital organ and kidneys.