Compositions and methods for inhibiting thrombogenesis
US5744457A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 6, 1995 |
| Grant date | Apr 28, 1998 |
| Priority date | — |
| Expiry date | Oct 6, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compositions and methods for inactivating thrombin bound to fibrin within a thrombus or clot, whereby the ability of clot-bound thrombin to catalytically promote further clot accretion is substantially diminished or eliminated. The compositions and methods of the present invention are particularly useful for preventing thrombosis in the circuit of cardiac bypass apparatus and in patients undergoing renal dialysis, and for treating patients suffering from or at risk of suffering from thrombus-related cardiovascular conditions, such as unstable angina, acute myocardial infarction (heart attack), cerebrovascular accidents (stroke), pulmonary embolism, deep vein thrombosis, arterial thrombosis, etc.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.