Apoptosis-modulating factors influencing the intracellular concentration of methional/malondialdehyde

US5744499A · kind A · utility

Assignee

• Centre International de Recherches Dermatalogiques Galderma (C.I.R.D.) Galderma · FR

Inventors

• Gerard Quash · Craponne, FR
• Alain Doutheau · Val-de-Reuil, FR

Key dates

• Filing date: Dec 28, 1995
• Grant date: Apr 28, 1998
• Expiry date: Dec 28, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Apoptosis (programmed cell death) in mammalian organisms is modulated, whether initiated or suppressed, for example for preventing and/or combating photoinduced or chronologic aging of the skin or for treating a wide variety of human afflictions, by administering thereto, for such prolonged period of time as is required to elicit the desired response, an effective apoptosis-modulating amount of at least one active species selected from among methional, malondialdehyde, or factor influencing the intracellular concentration of methional or malondialdehyde.