Sulfonyl- or sulfinylbenzoylguanidine derivatives

US5744641A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Rolf Gericke · Seeheim-Jugenheim, DE
• Manfred Baumgarth
• Klaus-Otto Minck · Ober-Ramstadt, DE
• Norbert Beier · Reinheim, DE

Key dates

• Filing date: Aug 9, 1996
• Grant date: Apr 28, 1998
• Expiry date: Aug 9, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

4-Sulfonyl- or 4-sulfinylbenzoylguanidines of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.6 and n have the meanings indicated, and their physiologically acceptable salts exhibit antiarrhythmic properties and, act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.