Methods and compositions for detecting and treating a subset of human patients having an autoimmune disease
US5747036A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Jun 7, 1995 |
| Grant date | May 5, 1998 |
| Priority date | — |
| Expiry date | Jun 7, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/24
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Provided are monoclonal antibodies, fragments, and derivatives thereof reactive with an epitope of the T cell receptor alpha chain variable region, V.alpha.12.1, on human T lymphocytes. The monoclonal antibodies are reactive with approximately 2% of CD4.sup.+ T lymphocytes and with approximately 5% of CD8.sup.+ T lymphocytes in peripheral blood cells in normal individuals and define a subset of individuals afflicted with an autoimmune disease, especially rheumatoid arthritis, that exhibit increased expression of the V.alpha.12.1 gene on CD8.sup.+ peripheral blood T lymphocytes when compared to normal individuals. Methods for treating individuals afflicted with such an autoimmune disease using V.alpha.12.1 specific reagents are described herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.