Bifunctional urokinase variants with improved fibrinolytic characteristics and thrombin inhibiting effect

US5747291A · kind A · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Gerd J. Steffens · Aachen, DE
• Stephan Wnendt · Aachen, DE
• Johannes Schneider · Stolberg, DE
• Regina Heinzel-Wieland · Darmstadt, DE
• Derek Saunders · Aachen, DE

Key dates

• Filing date: Sep 27, 1996
• Grant date: May 5, 1998
• Expiry date: Sep 27, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Bifunctional urokinase variants possessing improved fibrinolytic properties and thrombin inhibitory activities, plasmids used in the production of these polypeptides, as well as thrombolytic agents containing one of the bifunctional urokinase variants as active ingredient are described.