Isolated nucleic acid molecules which encode mammalian .alpha.2,8 polysialyl transferases

US5747326A · kind A · utility

Assignees

• La Jolla Cancer Research Foundation · US
• Boehringer Mannheim GmbH · DE

Inventors

• Rita Gerardy-Schahn · Hiddenhausen, DE
• Minoru Fukuda · Oodu, JP
• Jun Nakayama · Matsumoto, JP
• Matthias Eckhardt · Hannover, DE

Key dates

• Filing date: Jul 17, 1995
• Grant date: May 5, 1998
• Expiry date: Jul 17, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Isolated nucleic acid molecules encoding polysialyl transferases, and the polysialyl transferases themselves are disclosed. SEQ ID NOS: 1, 2, 7 and 8 present examples of these. The nucleic acid molecules and the proteins can be used diagnostically or therapeutically. Additionally, antisense oligonucleotides and antibodies are described, which can also be used diagnostically or therapeutically.