Ribozymes

US5747335A · kind A · utility

Assignee

• Gene Shears Pty. Limited · AU

Inventors

• James Haseloff · Cambridge, US
• Wayne Gerlach · Acacia Hills, AU
• Philip Anthony Jennings · Chatswood, AU
• Fiona Helen Cameron · South Canberra, AU

Key dates

• Filing date: Feb 8, 1994
• Grant date: May 5, 1998
• Expiry date: Feb 8, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/124
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds having highly specific endoribonuclease activity are described. The compounds of this invention, also known as ribozymes, comprise ribonucleotides having two hybridizing regions with predetermined sequences capable of hybridizing with a plant, animal or viral target RNA, a region of defined sequence and a base paired stem region.