Targeted gene expression using preproendothelin-1 promoters
US5747340A · kind A · utility
20Cited by
1References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 28, 1995 |
| Grant date | May 5, 1998 |
| Priority date | — |
| Expiry date | Feb 28, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention provides a vector for expression of a nucleic acid cassette in bronchial epithelial and vascular endothelial cells comprising a segment of the 5'-flanking region of the preproendothelin-1 gene, upstream from the transcription start site, the first exon of the preproendothelin-1 gene, and a nucleic acid cassette, wherein the nucleic acid cassette is located within the first exon, in sequential and positional relationship for expression of the nucleic acid cassette.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.