L-nucleoside analogues and pharmaceutical compositions

US5747473A · kind A · utility

Assignee

• MEDIVIR AB · SE

Inventors

• Bjorn Classon · Stockholm, SE
• Bengt Bertil Samuelsson · Skärholmen, SE
• Ingemar Kvarnstrom · Linköping, SE
• Lars Goran Svansson · Linköping, SE
• Stefan Carl Tore Svensson · Linköping, SE

Key dates

• Filing date: Aug 18, 1995
• Grant date: May 5, 1998
• Expiry date: Aug 18, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

##STR1## Novel antiviral compounds of formulae (1A) and (1B), wherein X and R.sub.1 -R.sub.4 are as stated in claim 1 in the form of an .alpha.- or .beta.-anomer or a mixture thereof, and pharmaceutically acceptable salts thereof, are disclosed, as well as a new method for preparation thereof. Said compounds can be used for treatment of infections caused by viruses requiring reverse transcriptase for replication, such as HIV and hepatitis B virus.