Heteroatom substituted benzoyl derivatives that enhance synaptic responses mediated by ampa receptors

US5747492A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• Gary Lynch · Irvine, US
• Gary A. Rogers · Basseterre, KN

Key dates

• Filing date: Jan 24, 1995
• Grant date: May 5, 1998
• Expiry date: Jan 24, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds ##STR1## are useful for enhancing synaptic responses mediated by AMPA receptors are disclosed, as are methods for the preparation thereof and methods for their use for treatment of subjects suffering from impaired nervous or intellectual functioning due to deficiencies in the number of excitatory synapses or in the number of AMPA receptors. The invention compounds can also be used for the treatment of non-impaired subjects for enhancing performance in sensory-motor and cognitive tasks which depend on brain networks utilizing AMPA receptors and for improving memory encoding.