Process for preparing benzoc!phenanthridinium derivatives, novel compounds prepared by said process, and antitumor agents
US5747502A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 16, 1992 |
| Grant date | May 5, 1998 |
| Priority date | — |
| Expiry date | Mar 16, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/473
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to benzoc!phenanthridinium derivative of the general formula A: ##STR1## wherein M and N individually represent a hydroxyl or lower alkoxy group, or M and N simultaneously represent a hydrogen atom or together form a methylenedioxy group, X.sup.- represents an acid residue or a hydrogen acid residue, and R represents a lower alkyl group, and a process for preparing such derivatives. The compounds exhibit both potent antitumor activity and platelet aggregation inhibition activity, and are expected to be useful for the treatment of tumors. The process has good reproducibility and may be effected under moderate conditions, and therefore the process is practically useful. In addition, hydrogen salts of the present compounds have an enhanced stability, which is an advantage in formulating the same into pharmaceutical preparations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.